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PDGF vs PRP vs Growth Factor Facials: What’s the Difference?

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You’ve likely seen buzz about growth factors, PRP, and other “regenerative” skin treatments. These innovations use the body’s own repair mechanisms to rejuvenate skin from within — improving tone, texture, and overall vitality. But what’s the difference between them?

What Are Growth Factors?

Growth factors are naturally occurring proteins that help regulate cellular repair and collagen production. When used in skincare or medspa treatments, they can support healthier, more resilient skin. Think of them as the body’s messengers for renewal — encouraging skin to heal, rebuild, and strengthen itself.

PRP: The Original Regenerative Booster

Platelet-Rich Fibrin (PRF) uses a small sample of your own blood, spun to separate concentrated platelets. It is a more potent solution that preserves the fibrin, making it last longer and enhances tissue regeneration.  This plasma is rich in growth factors and is often paired with microneedling or topical applications to help enhance skin rejuvenation.

PDGF and Advanced Growth Factor Treatments

PDGF (platelet-derived growth factor) is one of the key proteins found in PRF and newer topical formulations. It’s been studied for decades in regenerative medicine and plays an important role in stimulating collagen and elastin production. At Tribeca Medspa, our focus is always on clinically supported technologies that deliver visible, natural results.

(Avoids direct mention of exosomes; describes them conceptually as “advanced growth factor formulations.”)

Which Is Right for You?

During your consultation, your provider will evaluate your goals — from improving firmness to restoring post-summer glow — and recommend a personalized treatment plan. Many clients combine growth factor-based facials with other collagen-supporting modalities such as microneedling or laser treatments for comprehensive renewal.

The Takeaway

Whether you’re curious about PRF, PDGF, or emerging growth factor innovations, the science is clear: supporting the skin’s natural regenerative process can lead to smoother, stronger, more radiant results.

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